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Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University

作者:时间:2015-07-29点击数:

The Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE) at Northeast Normal University (NENU) was founded on the framework of the Institute of Genetics and Cytology that was founded in 1986 by the later member of the Chinese Academy of Sciences (CAS), Professor Shui Hao. The lab was started to construct in 2007, and formally approved in 2011 by the expert panel headed by the member of CAS, Professor Wu Weihua, organized by the Department of Science and Technology of MOE. Since its establishment, the lab has carried out systemic and intensive researches, obtained innovative academic achievements of significant impacts in the related respective fields, and trained a large number of qualified personals currently positioned at various universities in the country as university faculty members and scientists at biotech industries specialized in molecular epigenetics.

 

Lab Goals: Based on the ever-developing epigenetic theories and techniques, the lab aims to explore the common mechanisms that are conserved in animals, plants, and fungi, understanding the causes for epigenetic variations and their transgenerational inheritability. The long-term lab goal is to establish a first rate center in the northeast region of China for research and education specialized in molecular epigenetics

 

      Personnel: Currently, the lab includes 32 permanent staffs, including 17 professors and 10 assistant professors, 28 of the staff obtained their PhD or postdoctoral training abroad. The lab staff includes a member of the Chinese Academy of Engineering, winner of the National Science Fund for Outstanding Young Scholars, member of Discipline Assessment Groups of the Academic Degree Commission of the State Council, winner of Yangtze River Scholar professorship, member of the Thousand Talents Plan by the CPC Central Committee, member of the Program for New Century Excellent Talents in University, as well as Jilin province "Changbai Mountain scholar" Professor, and other distinguished professor titles. Overall, the personals constituting the lab are a strong team with shared as well as compensating expertise.

Currently, the lab is headed by professor Liu Bao, with help of Professor Wei Min as the deputy head, and Dr. Jiang Lily as the secretary.

 

       Scientific Advisory Committee:

Chair:

Dr. Li Yu, Professor in mycology, Member of the Chinese Academy of Engineering.

Vice Chair:

Dr. Xia Xianzhu, Professor in animal infectious disease and vaccine, Member of the Chinese Academy of Engineering.

Standing Members:

Dr. Cao Xiaofeng, Professor in plant genetics, genomics and epigenetics, Member of the Chinese Academy of Sciences.

Dr. Sun Qixin, Distinguished professor in crop genetics and breeding.

Dr. Ge Song, Distinguished professor in plant systematics and evolution.

Dr. Sun Chuanqing, Distinguished professor in crop genetics, molecular biology and breeding.

Dr. Zhang Tianzhen, Distinguished professor in crop genetics, genomics and breeding.

Dr. Han Fangpu, Distinguished professor in crop genetics, chromosome biology and breeding.

Dr. Zhang Tianzhen, Distinguished professor in crop genetics, genomics and breeding.

Dr. Dong Yingshan, Professor in crop genetics and germplasms.

Dr. Jiming Jiang, Distinguished professor in plant genetics, epigenetics and crop breeding (University of Wisconsin-Madison, USA).

Dr. Chuanbin Mao, Professor in nanotechnology and biotechnology (Oklahoma University, USA).

Dr. Diter von Wettstein, Distinguished professor in plant molecular biology and cell biology, crop genetics and epigenetics, Washington State University, Member of the National Academy of Sciences of the United States of America.

Major Research Directions: By integrating the traditional strength in biology at NENU, four distinct as well as mutually supportive research directions are formulated in the lab.

Direction I: epigenetic regulatory mechanisms in plant interspecies hybridization and/or polyploidization-induced heritable changes in gene expression. This direction mainly focuses on exploring the relationships between the hybridization and polyploidization events with epigenetic variations generated whereby, understanding the causing factors of epigenetic variation and its transgenerational inheritance.

Direction II: potential roles of epigenetic mechanisms in plant evolution and crop domestication, especially nascent polyploid species and crops. This direction mainly focuses on deciphering the roles of epigenetic variation in polyploid plant genome evolution and speciation, testing if epigenetic variations have been under human selection.

Direction III: epigenetic mechanisms in the regulation of gene expression and genome stability in animal and human cells. This direction mainly focuses on analyzing the correlative and causal features between epigenetics and genome stability in normal and tumor cells as well as defining the molecular underpinnings.

Direction IV: application of epigenetic variations in crop improvement and major human disease diagnostics and treatments. This direction mainly focuses on exploring the feasibility to apply induced epigenetic variations in crop germplasm enhancement, and naturally occurred epigenetic variants in diagnosing human diseases and using this as therapeutic targets to screen for effective medicines.

 

Major achievements: Since its establishment in 2011, significant achievements in each of the foregoing research directions have been made in the lab. As of December, 2015, the lab as the first affiliation has published 120 peer-reviewed search articles in the mainstream international journals of the fields, including PNAS, Mol Biol Evol, Plant Cell, Cancer Research, New Phytologist, BMC Biology, Plant Journal, Plant Physiology, Molecular Plant, Cell Death & Disease, J Cell Sci, Genetics, and etc. In addition, as a co-affiliation, the lab published 45 articles on various renowned scientific journals, including Nature, Nature Biotechnology, Nature Communications, PNAS, MBE, Plant Cell, and Cancer Research. Professors Liu Bao and Wang Shucai are invited as associate or guest editors by several international scientific journals. Nearly 20 lab personnel were invited to attend and present lectures in domestic and international conferences. More than 20 personals were invited to give lectures and conduct academic exchanges by other universities and institutions both at home and abroad. In addition, the lab has written 5 books, patented 18 practically voluble achievements, obtained 12 scientific awards, released about 10 new crop cultivars. Significantly, many original research findings were successfully converted to practical utilizations and commercial products, which have made significant contributions to the local economy.

实验室地址:吉林省长春市人民大街5268号东北师范大学综合实验楼

Key Laboratory of Molecular Epigenetics of MOE.Northeast Normal University.